brentuximab vedotinBrentuximab vedotin (brentuximab vedotin) is the trade name adsetris (adcetris). The drug is approved to treat two types of cancer. InHodgkin's lymphomaassigned patients who received autologous stem cells or other treatments that were ineffective. In systemic anaplastic large cell lymphoma adsetris recommended after application of at least onecancer drug , Which has not produced results.

Brentuximab vedotin refers to a group of monoclonal antibodies that represent copies of a single antibody. They are created in the laboratory. Monoclonal antibodies seek out the cancer cells, targeting specific proteins on their surface. Brentuximab vedotin directed to protein - CD 30 which is located on cells of Hodgkin lymphoma and anaplastic large cell lymphoma. The drug is attached to the CD 30, and delivers the drug to the cell, and then the drug destroys it.

Adsetris only appointed doctor, therapy is performed under its direct control.

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Not recommended for use brentuximab vedotin:

  1. If you have an allergy to any component of the drug. Should inform the doctor about any allergic reactions to other drugs, as well as on the available types of allergies - for food, dyes, preservatives or animal.
  2. When there are serious or moderate liver problems.
  3. When kidney disease.
  4. If blood or bone marrow diseases (eg, neutropenia).
  5. When the patient takes bleomycin (Blenoxane®), simultaneous use can cause serious side effects.
  6. There neurological damage (peripheral neuropathy - burning sensation, numbness, tingling, pain in arms and legs).
  7. In the presence of infection.

Important points that should be remembered in the treatment of brentuximab vedotin

  1. It is important to inform the doctor about the side effects occurring.
  2. Pregnancy and contraception. Adsetris can harm the baby developing in the womb. You must use effective methods of contraception during treatment and for six months thereafter. Studies in pregnant women have demonstrated a risk to the fetus.
  3. Breast-feeding. One can not breastfeed during bretuksimabom treatment, because the drug may manifest in breast milk.
  4. The drug contains sodium. It is necessary to take this into account, if the patient is on a diet with a controlled sodium diet.
  5. There are no studies on the use of the drug adsetris (adcetris) on children has not been established safety and efficacy. The same applies to the elderly.
  6. Please inform the oncologist about any other medications the patient is taking, including vitamins, dietary supplements, OTC drugs. Some of these may react with each other.

How is treatment with brentuximab vedotin?

Before receiving treatment, the patient should be aware of all of its risks and benefits. During treatment, it is important to work closely with your doctor.

The drug enters the body intravenously via cannula. Duration of procedure - 30 minutes. Also, the patient may receive other medications (eg, acetaminophen, steroids) to prevent possible allergic reactions. Repeated every 3 weeks for up to 16 times until there are results. Therefore, the therapy can take up to 48 weeks, almost a year.

Side effects brentuximab vedotin

There may be several adverse effects of treatment, lighter or heavier. Often, a side effect is decreased or amplified in the course of therapy. Sometimes their number increases. It affects overall health, medication dosage, the number of procedures.

Common side effects

10 out of 100 people have one or more of the following effects of therapy:

  1. Numbness or tingling in the fingers and toes occurs in 4 out of 10 people (40%).
  2. Nausea is marked in the same percentage ratio (38-42%) it is usually well managed via antiemetics.
  3. Fatigue and weakness occurs in 4 out of 10 (41-49%) patients during and after treatment. Most people notice that they return to normal life within 6 to 12 months.
  4. Diarrhea is in 3 out of 10 people (29-38%). It is recommended to drink plenty of fluids. If it continues for more than 3 days and becomes severe, you should inform your doctor.
  5. High temperature (29-38%).
  6. Skin reactions occur in 1 out of 4 people. This can be a rash (27-31%), similar to the acne on the face, neck and torso; dryness and itching (17-19%).
  7. Constipation happens in 2 of 10 patients (16-19%). If it lasts more than 3 days, you should tell the doctor, they will be discharged laxatives.
  8. Increased risk of contracting infections in connection with a decrease in white blood cell count. The following symptoms may occur: headaches, muscle aches, cough, sore throat, pain when urinating, cold and chills. Severe infection can be life-threatening.
  9. Allergic reactions can occur during treatment that will cause fever, chills, headache and malaise. Often the reaction is more severe - a wheezing, itching, blood pressure drop. The nurse will provide medication to prevent a reaction.
  10. Headaches (16-19%).
  11. Muscle pain (16-17%).
  12. Back pain (10-14%).
  13. Loss of appetite occurs in about 1 in 10 people.
  14. Loss of fertility - the patient or the patient could no longer have children. Therefore, before treatment it is important to discuss this with your doctor.
  15. Dyspnea (13-19%), and shortness of breath.

Rarer side effects adsetrisa (adcetris)

There is one or more adverse events in the treatment of 1-10 people within a hundred:

  1. Fatigue and shortness of breath due to lower level of red blood cells (anemia - 33-52%) - you may need a blood transfusion.
  2. Hematoma due to reduced platelet (16-28%) - observed nosebleeds, gingival bleeding after brushing. You may experience numerous tiny red spots (petechiae) or bruises on the hands or feet.
  3. Changes in the liver, but weak enough to cause any symptoms. Normal state, as the treatment is over. Regular blood tests to check that the body is functioning normally.
  4. Thinning hair (alopecia 13-14%).
  5. High levels of blood sugar.
  6. Dizziness (11-16%).
  7. Cough (17-25%).
  8. Painful and swollen joints.
  9. Chills (12-13%).
  10. The which the lead Infections Severe to high temperature, Increased heart rate The, breathing Problems view .

Rare side effects brentuximab vedotin

It appears in one hundred patients.

  1. Malignant exudative erythema.
  2. High levels of uric acid in the blood due to the collapse of the tumor cells. The need for regular blood tests to monitor its content. Drinking plenty of fluids helps to get rid of the excess of the substance.
  3. A viral infection that affects parts of the brain tissue develops within a few weeks or months. This can lead to confusion, difficulty thinking, memory loss, vision changes, weakness, difficulty walking, loss of balance. These violations relate to the phenomenon of - progressive multifocal leukoencephalopathy.