vemurafenib (vemurafenib)The drug vemurafenib (Vemurafenib), also known as zelboraf (Zelboraf ® - trade name) is used to treat metastatic melanoma , which can not be removed using surgery.

The drug vemurafenib relates to kinase inhibitors (also known as blockers of cancer growth), inhibiting the production of proteins called kinases, which control cell growth and division.

Zelboraf - preparation of biological therapy. It stops the synthesis of BRAF protein that promotes the development of certain malignant cells. Almost half of all cases of melanoma patients have an excessive amount of the protein, which is caused by changes in the BRAF gene.

Vemurafenib for the treatment of advanced melanoma, when the cancer cells have mutations in this gene. They lead to the synthesis of the mutated BRAF protein, which helps to increase melanoma. Zelboraf blocks the altered protein, stopping the development of cancer. To check the mutation genetic test is conducted on the basis of the tumor sample.

How to take vemurafenib?

Patient receives 4 tablets in the morning and 4 - twelve hours, the total dose at a time - 960 mg (4 x 240 mg).


  1. The drug is taken at the same time in the morning and evening, every day.
  2. You can not take it on an empty stomach is the best option at meal time or immediately after a meal.
  3. Tablets should be swallowed as a whole (not liquid) with water.

It is important to take the medicine according to doctor's instructions. Admission zelborafa on an empty or full stomach affects the amount of drug entering the blood stream. You can not stop the treatment without consultation with the oncologist.

Vemurafenib treatment is carried out as long as he controls the progression of the disease. In rare cases it is necessary to stop treatment due to severe adverse consequences.

What to remember about taking vemurafenib?

  1. It is important to take the drug according to doctor's orders.
  2. You should always talk to doctors in the treatment of other diseases that the patient is undergoing treatment zelborafom who can not stop or start again without consultation with oncologist.
  3. Tablets should be stored in its original packaging, at room temperature, away from sources of heat and sunlight.
  4. Keep the medication in a secure place, without access for children.
  5. If you miss a dose zelborafa, you need to consult a doctor for advice, you can not take a double dose to make up for the missed.

For more information about the drug vemurafenib

  1. Other medications. Some medications can have adverse effects when taking zelborafa. Therefore, it is important to inform your doctor about any medications the patient is taking, including supplements, as well as further therapies. Without consulting a doctor should not take any drugs.
  2. Immunization . During treatment zelborafom patient should not be vaccinated with live vaccines (rubella, mumps, measles, BCG, yellow fever, herpes zoster), and six months thereafter. Is it safe to get vaccinated against the flu.
  3. Fertility . This therapy using zelboraf can affect fertility. Therefore, it is important to discuss this with your doctor before starting treatment.
  4. Contraception . Little is known about the consequences of the impact of vemurifeniba on the developing fetus. Therefore, it is not recommended pregnant woman or a child becomes a father - the man at the time of taking this drug. No information about the present, whether zelboraf in semen or vaginal fluid. In order to protect the partner, it is safer to use a barrier method of contraception during therapy and for several months thereafter.
  5. Breastfeeding . There is a chance that zelboraf may be present in breast milk, so women are advised not to breast-feed during treatment and for a few months later.

Possible side effects zelboraf

The reaction of each organism to cure individual. In some patients, there is a small number of side effects, while others experience more. Described herein are generally undesirable consequences zelborafom therapies that have been studied.

The side effect may increase in the course of treatment, the number of adverse effects can increase. It will be affected by factors such as general health, Zelboraf dosage, treatment with other drugs.

  1. Moderate changes in the skin. It can be itchiness, rashes, dryness, peeling skin, warts occurrence - 3 out of 10 people. It is important to inform your doctor if you experience any of these symptoms will be assigned creams or ointments.
  2. Increased sensitivity to light . The therapy zelborafom can develop this side effect (even on a cloudy day) - 5 of 10 people. Before going outdoors should use a sunscreen with a high protection factor - not less than 30. Some doctors recommend the use of protection by a factor of 50. Also it is necessary to cover the exposed areas of the body and clothing to wear top hats.
  3. Loss of appetite . Some people lose their appetite, taking zelboraf. This can manifest itself in a mild form and last for several days. If the condition worsens, consult a dietitian. He will give advice on how to improve this situation and to maintain normal body weight.
  4. Changes in taste . The patient is sometimes seen during treatment with vemurafenib, that the taste of food has changed. A dietitian can provide recommendations on how to handle this situation.
  5. Diarrhea . The drug can cause diarrhea. Usually this symptom control with medication. If he gets a long and severe, should consult a doctor. It is necessary to drink plenty of fluids.
  6. Constipation . Zeboraf sometimes causes constipation. In this case, the patient makes use of the amount of fluid inclusion in the diet of foods rich in fiber, performing light exercise. You may need laxatives.
  7. Nausea and vomiting . Observed in 2 out of 10 patients. Your doctor may prescribe antiemetic drugs to reduce or prevent these symptoms. If the state is not normal, it is necessary to notify the oncologist. He will prescribe other medications that may be more effective.
  8. Overwork . Tiredness while taking vemurafenib is observed, but in a gentle manner. It is important not to expose the body exhausting work, getting enough rest, but balance it with light physical exercise - short walks.
  9. Effect on the hair . When receiving zelborafa hair can become thinner, observed in 4 out of 10 people. This applies as body hair (eyelashes and eyebrows) or on the head. Most changes - temporary. In rare cases, they become permanent. Sometimes when hair grow, they acquire different textures.
  10. Fluid retention . Most often, there is swelling of the ankles. Basically, this symptom does not require treatment, but sometimes require diuretics.
  11. Cough . Zelboraf is able to cause a cough. If this happens, your doctor may prescribe medications.
  12. Fever and chills . These symptoms may occur early in treatment, do not last long. Sometimes the doctor will prescribe medication. A number of patients with fever occurs from time to time in the course of therapy.
  13. Headaches . Vemurafenib can very rarely cause a headache. In such cases, take analgesics.
  14. Effects on the liver . Rarely zelboraf provokes changes in the liver. The physician should closely monitor this, making regular blood tests to check the operation of the body.

Side effects when taking zelborafa occurring more rarely - from 1-10 per 100 people - one or more unwanted manifestations:

  1. Other types of skin cancers . One quarter of patients develop other types of skin cancer - squamous cell and basal cell less frequently while taking vemurafenib. As a rule, they are successfully treated with surgery. Also, the patient will be recommended to regularly check for the presence of skin cancer symptoms, when some area is covered with scales, bleeds or becomes rigid horn cover. Doctor regularly check your skin in the process of therapy and six months thereafter.
  2. Acral erythema . Patient at a reception zelborafa may notice redness of the palms of the hands and soles of the feet, and pain or swollen state. There may be numbness or tingling. If the irritation does not disappear, appear rash, your doctor will reduce the dose or temporarily stop treatment. Very rarely stop treatment.
  3. Vision problems . May experience symptoms such as pain, swelling, redness, rarely changes such as blurred vision.
  4. The weakness of the facial muscles . Zelboraf capable of provoking weakness or paralysis of one side of the face. Paralysis is usually temporary and disappears after discontinuation of the drug.
  5. Muscle and joint pain . The physician may prescribe analgesics and / or anti-inflammatory agents to alleviate the condition.
  6. Violations of the heart . Vemurafenib in a small number of people can cause irregular heart rhythm. The appearance of this symptom you should immediately inform your doctor. Prior to initiation of therapy, will be carried out tests, checking the work of the heart. They can be repeated during the treatment.
  7. Also, when receiving vemurafenib celebrate weight loss, dizziness, inflammation of adipose tissue.

Rare side effects of Zelboraf:

  1. Allergic reaction. Zelboraf can sometimes cause serious allergic reactions, however, are rare. Symptoms: swelling of the face, lips or tongue, hives, dizziness or shortness of breath. It is important to as quickly as possible to see a doctor and stop the treatment.
  2. Severe skin reaction called Stevens-Johnson syndrome. The skin becomes red and painful blisters. For most patients with such a reaction treatment is stopped, they are sent to the hospital to control symptoms.
  3. Violations of nerves that can cause pain and numbness.
  4. Changes of view due to the blocking of blood vessels in the back of the eye.
  5. Redness and swelling of vessels.
  6. Increased risk of cancer in other parts of the body other than the skin - your doctor will regularly check the head, neck, mouth, lymph nodes. The patient is periodically passes RT.
  7. Abdominal pain, caused by inflammation of the pancreas (pancreatitis).