Chemotherapy for breast cancerChemotherapy is the medicinal treatment of malignant tumors, drug administration is carried out intravenously or orally. They travel through the bloodstream and reach cancer cells throughout the body. Therapy is conducted in cycles that alternate with periods of recovery. As a rule, the treatment lasts for several months.

The cost of chemotherapy for breast cancer in Israel - from $ 2700 per course.

Medical service will assist in the organization of chemotherapy for breast cancer in the clinics of Israel. The level of development of medicine of the State will allow for the most effective treatment.

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types of chemotherapy in breast cancer

Adjuvant chemotherapy in the treatment of breast cancer in Israelis performed after surgery. Such treatment is administered to patients with no obvious signs of cancer after surgery. The goal of adjuvant therapy - to destroy malignant cells that might survive and remain unnoticed. This sub-type of treatment reduces the risk of relapse.

Even in the early stages of the disease the cancer cells can break away from a primary tumor focus and spread throughout the body via the bloodstream. They do not show themselves, not shown on the diagnostic results. But if these cells start to grow, they cause the formation of new tumors in other locations. The goal of adjuvant therapy - to destroy them.

Neoadvantnaya chemotherapy is given before surgery. Often, the same techniques are used here as in the adjuvant, only before and not after the operation. The main advantage of neoadvantnoy chemotherapy is that it is able to reduce large tumors to a size where it is possible to carry out surgical treatment. Another advantage is that doctors can see the reaction of the woman's body to chemotherapy.

Leading experts on the treatment of breast cancer in Israel is Julia Greenberg . Dr. Moshe Inbar and Dr. Irina Stefanski. They have extensive experience in the treatment of breast cancer with the aid of chemotherapy, radiotherapy and by other new methods.

In some cases, malignant tumors of breast are too big, so they can be surgically removed at the time of diagnosis. This type of cancer is called locally advanced. With chemotherapy, reduce the size to remove surgically.

For advanced breast cancer chemotherapy may be used as the primary treatment when metastases penetrated beyond the breast or the axilla. The duration of therapy will depend on how fast the tumor is reduced, how much time and how a woman carries the treatment.

After surgical treatment in Israel recommended to test the patient "Onkotayp" by which determine the potential benefit of chemotherapy.

Scheme chemotherapy for breast cancer

In most cases, especially the adjuvant and neoadjuvant treatment more effective is a combination of drugs, and not any one drug. Used different chemotherapy regimens, and is not specific to any one that is undoubtedly the best.

The most common chemotherapeutic drugs for the treatment of early breast cancer stages are anthracyclines, which suppress gram-positive bacteria and possess regimens breast cancerantitumor activity (Doxorubicin hydrochloride (Adriamycin), Epirubicin (Epirubicin)), and taxanes (paclitaxel / Taxol ®, Docetaxel / Taxotere ®). They may be administered in combination with drugs such as cyclophosphamide (Cytoxan ®), Fluorouracil ( 5-FU).

Some of the most common schemes of breast cancer chemotherapy:

  1. CAF (or FAC): Cyclophosphamide, Doxorubicin (Adriamycin) 5-FU.
  2. TAC: Docetaxel / Taxotere, doxorubicin (Adriamycin), and cyclophosphamide.
  3. AC → T: Doxorubicin (Adriamycin) and cyclophosphamide followed by administration of Taxol (paclitaxel) or Taxotere (docetaxel).
  4. FEC: → T: 5-FU, epirubicin and cyclophosphamide followed by administration of Taxotere (docetaxel) or Taxol (paclitaxel)
  5. TC: Taxotere (docetaxel) and cyclophosphamide.
  6. TCH: Taxotere (docetaxel), carboplatin and Herceptin (trastuzumab)

Guide world medical protocols, as well as development of unique chemotherapy protocols are a high efficiency of cancer treatment in Israel of factors.

To a lesser extent used regimens spurge cancer:

  1. CMF: Cyclophosphamide (Cytoxan ®), Methotrexate * (Methotrexate *) and Fluorouracil (5-FU).
  2. → CMF: Doxorubicin (Adriamycin), followed by CMF scheme.
  3. EC: Epirubicin (epirubicin) and cyclophosphamide (Cytoxan ®)
  4. AC: Doxorubicin (Adriamycin), cyclophosphamide (Cytoxan ®).

Other chemotherapy drugs that are useful in the treatment of women with breast cancer:

  • Platinum agents (Cisplatin, Tsarboplatin).
  • Vinorelbine (Navelbine ®)
  • Capecitabine (Xeloda ®)
  • Liposomal doxorubicin (Doxil ®).
  • Gemcitabine (Gemzar ®).
  • Mitoxantrone.
  • Ixabepilone (Ixempra ®).
  • ABRAXANE (Abraxane)
  • Eribulin (Halaven ®)

Doctors spend chemotherapy cycles, the period of treatment is replaced rest period to allow the body to recover from the effects of the medication. The therapy begins with the first day of each cycle, but the schedule varies depending on the drugs used. For example, some are given only for the first day of the cycle, others - every day for 14 days, etc. Cycles often last for 2 or 3 weeks, but vary according to the specific drug or combination thereof.

Adjuvant and neoadjuvant chemotherapy is generally carried out for 3-6 months, depending on the used drugs. Treatment may last longer for advanced breast cancer, its period due to efficacy and side effects.

High-dose chemotherapy for breast cancer

Doctors have found that high-intensity courses of chemotherapy may reduce the likelihood of recurrence and improve survival. This means the following: the same chemotherapy treatment cycles, which give every three weeks, begin to give every two weeks. The drug (growth factor) can help increase white blood cell count after chemotherapy, to make sure that the number of leukocytes returned to normal at the start of the next treatment cycle. This approach is used for neoadjuvant and adjuvant therapy. However, it can lead to more significant side effects, as well as high-dose chemotherapy is not suitable for everyone.

Side effects of chemotherapy for breast cancer

adjuvant chemotherapy for breast cancerChemotherapy drugs attack cells that divide rapidly, so they are effective against cancer. But there are cells in the body, such as bone marrow cells, the mucous membrane of the mouth and intestines, hair follicles, also divide quickly. Together with malignant influences on them chemotherapy. For some women, there are many side effects, some - a few.

To reduce the side effects of chemotherapy, Israeli doctors have successfully used a variety of modern products and techniques, for example, colony stimulating factors to specific schemes cytostatics (against neutropenia, anemia).

Negative effects caused by chemotherapy drugs view, their number and duration of administration. The most common side effects are:

  • hair loss;
  • oral ulcers;
  • an increase or loss of appetite;
  • nausea and vomiting;
  • low blood cell counts.

Chemotherapy can affect blood-forming bone marrow cells that will cause an increased risk of:

  • Infections due to insufficient number of white corpuscles;
  • hematomas and bleeding due to the low platelet count;
  • develop fatigue due to low levels of red blood cells and other reasons.

These side effects usually do not last long and go after treatment.

menstrual changes

For young women the changes in the menstrual cycle - a common side effect of chemotherapy. Premature menopause or infertility may be an unwanted consequence of the temporary or permanent nature. The older the woman, the higher the probability of the adverse effects of treatment. When this happens, there is a risk of bone loss and osteoporosis. Prescribe medicines that treat or prevent bone loss.

Even if the month ends when the woman is on chemotherapy, she is able to become pregnant. Pregnancy during chemotherapy can lead to birth defects and interfere with the process of the struggle with cancer. Therefore, a doctor discussed the possibility of the use of contraceptives.

If the woman was pregnant when diagnosed with breast cancer, there is a possibility of treatment. Some chemotherapy drugs are safe during the last 2 trimesters.

Also, before starting treatment with the doctor discusses the question of the desire of the patient in the future to have children.

neuropathyChemotherapy for breast cancer

Many drugs used to treat breast cancer, including taxane (docetaxel and Taxol), platinum agents (carboplatin, cisplatin), vinorelbine, eribulin and Ikzempra can damage the nerves outside the brain and spinal cord. Sometimes this leads to the appearance of symptoms (mainly in the hands and feet), numbness, pain, burning or tingling, sensitivity to heat or cold, weak. In most cases, they are as soon as treatment is stopped, but can continue for a long time in some women.

damage to heart

Doxorubicin, Epirubicin and a number of other drugs can lead to irreversible damage to the heart, called cardiomyopathy. The risk depends on the amount and duration of drug use, especially in high doses. Doctors watch closely for these side effects. They monitor the patient's heart using the MUGA test (Test of Nuclear Medicine, evaluates the function of the heart ventricles), or echocardiograms before taking one of these drugs. Doctors carefully monitor the dose, follow the signs. If heart function begins to decline, treatment with these drugs is stopped. However, in some patients, the damage process proceeds for a long time: the symptoms may not appear for months or even years after therapy was stopped.

Hand-foot syndrome

Some chemotherapy drugs such as capecitabine (Capecitabine) and Doxorubicin (Doxorubicin), may irritate the palms of hands and soles of the feet. Early symptoms include numbness, tingling and redness. If the condition worsens, there may be swelling, soreness, rash, patchy scaling, itching. No specific treatment, but some creams can help. The symptoms gradually disappear when the reception is stopped drugs or reduce the dose. The best way to prevent this syndrome, tell your doctor about the early signs.

Side effects of chemotherapy for breast cancer: effects on the brain

Chemotherapy for breast cancerMany women who are being treated for breast cancer, reported a slight decline in mental performance. There are some problems with concentration and memory, which can last for a long time. According to studies, these symptoms usually disappear within a few years.

Side effects of chemotherapy for breast cancer: increased risk of leukemia

Very rarely, chemotherapy can cause bone marrow damage, which triggers the development of myelodysplastic syndrome (MDS) or acute myeloid leukemia. It occurs mainly in the period of 10 years after the end of treatment.

Malaise and fatigue

After chemotherapy, many women do not feel as healthy as it once was. There is a residual feeling of pain, loss of physical activity.

Fatigue is a very common symptom after this treatment for women. It can persist for several years.

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