+ intravesical chemotherapy for bladder cancerIsraeli clinic in the treatment of cancer of the bladder can offer:

  1. Innovative therapies, including gene therapy, immunotherapy, chemotherapy.
  2. Minimally invasive laparoscopic and robotic surgical procedures.
  3. Advanced reconstruction technology.
  4. Services of highly qualified and experienced surgeons.
  5. 3D conformal and IMRT radiotherapy.

Israeli researchers continue to explore new combinations of chemotherapy drugs and their dosages to improve performance, slowing the progression of the disease and reduce the side effects.

Medical service «Tlv.Hospital» offers the organization of treatment in private and public clinics in Israel as soon as possible, with the best doctors in the most comfortable conditions of stay in the country.

Let us consider how untreated cytostatics for malignant tumors of the bladder.

Chemotherapy for bladder cancer, the surface forms

To reduce the risk of the disease returning after surgery may be recommended chemotherapy directly into the bladder or intravesical chemotherapy.

This treatment destroys abnormal cells. When the cytostatic agent is administered into the bladder, the drug comes in direct contact with cancer cells located on the organ mucosa.

Intravesical chemotherapy is different from intravenous, which is sometimes used for the treatment of invasive bladder cancer. Since the drug enters into the body do not develop side effects such as nausea or hair loss. Cytostatic not actually absorbed into the blood, so rarely have an impact on the rest of the body.

Intravesical chemotherapy for bladder cancer

Most patients are assigned to one procedure after surgery. If there is a risk of recurrence, it is usually necessary to have more procedures. When this probability is intermediate, held a course of treatment, once a week for about six weeks.

Intermediate risk means:

  • Papillary Ta gribopodobny, grows only in the inner layer of the bladder wall. It has 1 degree (cancer cells grow slowly and are readily identified) or grade 2 tumor development (grow faster and look more abnormal). The size of tumors larger than 3 cm, or there are several tumors, or they keep coming back.
  • T1 tumor began to grow into the layer of connective tissue under the mucous membrane, has a degree of 2, the size of less than 3 cm in diameter.

How is the intravesical chemotherapy for bladder cancer?

If the transaction is assigned to chemotherapy, it carried out a few hours later.

When detected in the urine of large amounts of blood, the procedure may be postponed until the next day. If necessary, additional treatment with cytostatics, it will be performed in the outpatient department of a hospital. After treatment is complete, the patient will be discharged. The doctor will provide detailed information on the preparation.

Perhaps a specialist will offer restrict fluid intake prior to chemotherapy for bladder cancer. Its large quantity can lead to discomfort of overcrowding in the body and decrease the volume will increase the concentration of chemotherapy.

Patients who take diuretics, will have to postpone their reception at a later time after the therapy. Also, the doctor should be warned about any other medicines that the patient receives, as well as a possible ailment to cure. Chemotherapy for bladder cancer will be delayed if the patient feels unwell, or have the infection in the urine.

During the procedure, the nurse will put the catheter into the bladder through which the fluid inside the organ with chemotherapeutics will flow. Most often used mitomycin C, doxorubicin or epirubicin, sometimes - gemcitabine.

After cytostatic agent is introduced, the catheter is removed. It is recommended for at least an hour unable to urinate. This may cause certain inconvenience, but gives the time of chemotherapy drugs act. Sometimes a catheter is left and clamp to hold the medicine inside the body. At this time, it is possible, for example, walking.

After processing is finished, you can go to the toilet. If the catheter is left, chemotherapy drug is drained before it is removed.

Within six hours after treatment will need to take certain precautions to protect yourself and others from coming into contact with cytostatic agent:

  1. If the patient - man, avoid splashing urine on the toilet seat. Flush the toilet twice.
  2. Wash the skin thoroughly with soap in the genital area after urination to remove drug residues.
  3. Wash hands thoroughly after using the toilet.
  4. Drinking is not less than 2-3 liters of liquid per day for 48 hours after each treatment to eliminate the drug from the bladder.

Potential side effects

The following undesirable phenomenon may be a consequence of inflammation wall of the bladder (cystitis):

  • Frequent urination.
  • Pain or burning during urination.
  • Blood in the urine.

During the day - the two state should improve. Ease irritation of the consumption of large amounts of fluid. It may help reception painkillers.

In some patients, sometimes a red rash on the hands and feet. If this happens, you must be sure to inform your doctor.

If the state is not normal, or there is fever, changes color or smell of urine, it is necessary to contact a specialist immediately. Symptoms may indicate the presence of infection in the urine.

protection partner

You need to use a condom during sex within the first 48 hours after chemotherapy for bladder cancer. This protects partner from any drug which may be present in semen or vaginal fluids.

Contraception

This treatment is contraindicated in pregnancy, as cytostatics can harm the developing baby. It is important to use effective contraception during treatment. This question can be discussed with your doctor.

Chemotherapy for bladder cancer, invasive forms

Chemotherapy - a method that uses cytotoxic drugs in the fight against malignant cells. When invasive cancer it is given intravenously, and chemotherapy drugs circulate in the bloodstream, reaching abnormal cells in any part of the body.

Chemotherapy is prescribed:

  1. Before surgery or radiation therapy to reduce tumors and reduce the chance of the disease returning.
  2. At the same time as radiotherapy - the so-called chemoradiation therapy to increase the effectiveness of treatment.
  3. After surgery, if there is a high probability of the return of the disease. It is not known how effective it is, so it is usually administered as part of a clinical trial.
  4. As the main treatments for metastatic cancer.

Combination of drugs, usually given over several days.

The patient will receive cytotoxic agents every few weeks for several months. Drugs gemcitabine and cisplatin is often used to treat this disease. Basically, the following combinations: methotrexate, vinblastine, doxorubicin and cisplatin (MVAC) and cisplatin, methotrexate and vinblastine (CMV).

Chemotherapy for metastatic bladder cancer

cytostatic treatment is prescribed as well, when the neoplastic process has gone beyond the boundaries of the bladder and even into other parts of the body. Chemotherapy can help to reduce or slow the growth of tumors and reduce symptoms of the disease. The type of treatment will be determined by the fact how far the cancer has spread and good physical condition in a patient. a combination of chemotherapy drugs or a cytostatic agent can be administered.

Many people are wary this method due to potential side effects, but they can be successfully controlled with medication.

To decide on the treatment of metastatic cancer can be difficult. It is important to talk to your doctor about the pros and cons of treatment for a particular situation. May benefit from a discussion with your family and loved ones. If a patient chooses not to do chemotherapy for bladder cancer, other drugs and how to deal with the symptoms can be used. Doctor to discuss these issues with the patient.

Innovative therapies

Microwave (therapeutic) hyperthermia, chemotherapy and intravesical bladder cancer is considered as one of such methods of treatment.

During the procedure, a probe inserted into the bladder directs heat to the body of the mucous membranes. At the same time injected chemotherapy drug inside. Studies continue to find out a mechanism for increasing the effectiveness of cytostatic treatment under the influence of hyperthermia.

Intravesical chemotherapy with electrical stimulation

A number of studies suggest the introduction of cytostatic mitomycin in bladder along with electrical stimulation. Under the action of electric current cells absorb a larger amount of chemotherapy drug.

Possible side effects

Cytostatic agents can cause some unwanted effects, but they can be successfully controlled with medication.

  1. the risk of infection. This type of treatment is able to reduce the production of the bone marrow white blood cells, making the person more prone to infection. This effect starts generally seven days after initiation of therapy, and resistance to reach its lowest point in ten - fourteen days after treatment. Then the number of blood cells increases and usually return to normal within twenty-one - twenty-eight days.
  2. Bruising or bleeding. Chemotherapy for bladder cancer can reduce platelet synthesis that promote blood clotting. It is important to tell your doctor if you experience any bruising or bleeding for no reason - from the nose, gums, skin rashes.
  3. Anemia. anemia due to decreased number of red blood cells that will cause fatigue and shortness of breath. You may need a blood transfusion, if the number of red blood cells is too low.
  4. Vomiting and nausea. These symptoms may develop within a few hours after treatment and last up to a day. Doctors prescribe very effective antiemetic drugs to prevent or reduce these symptoms.
  5. Inflammatory process may occur in the mouth, small ulcers. Reduce the likelihood of this side effect may consumption of large amounts of liquid, as well as regular and accurate care of teeth with a soft toothbrush. If any of these problems appear, the physician prescribes mouthwashes and drugs that prevent or fight infection.
  6. Poor appetite. If the patient does not feel the taste of food during treatment, you can try replacing some meals nutritious drinks. They can recommend a doctor or dietitian hospital.
  7. Hair loss. Specific cytostatic agents can trigger hair loss. If this happens, there are many ways to hide using hats, scarves or wigs. The hair will start to grow again in three - six months after therapy ends.
  8. Feeling tired. Many patients experience fatigue during treatment, especially towards the end. We must try to balance rest periods with simple exercises, such as walking, for example, when the patient is unable to do so.
  9. Early menopause. Women who have not reached menopause, it may occur earlier in connection with the treatment. Its symptoms include hot flashes and vaginal dryness. If this happens, the doctor at the hospital will be able to advise on the procedures that can help to combat the signs of this phenomenon.

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