Secondary Liver Cancer Secondary Liver Cancer - a metastatic tumor or metastases of malignant diseases such as skin cancer (melanoma), gastric , bowel, pancreas, lung, breast, ovaries.

You can learn about treatment in Israel:

  1. Public and private medical centers - how to choose a foreign patient?
  2. Medical tourism in Israel, treatment without intermediaries - the truth and fiction

The choice of treatment for a given disease will depend on a number of factors:

  • the place of origin of the primary chamber;
  • the presence of metastases in other organs;
  • liver injury segments.

If you had put this diagnosis, and you are considering treatment abroad, an excellent option would be for Israel to its many medical centers.

Our company, the focal point «Tlv.Hospital», being a conduit for foreign patients in the Israeli health care system will be able to provide high-quality treatment. We will select for you the best specialists, clinic, where the maximum aid, if necessary will involve the possibility of a number of medical institutions (we interact on a contractual basis with these hospitals like Assuta, Ichilov, Rabin, Asaf ha Rofé, Herzliya Medical Center, Sheba will be given to , Tel Aviv).

Also will assist in the selection of property, transfer, support at all stages of the treatment process, on the patient's desire to provide additional services at an acceptable cost.

Our company has accumulated considerable experience in the field of medical tourism in Israel - more than 10 years and has acquired a large amount of knowledge about the specifics of the health of the country.

Treatment of metastases in the liver - chemotherapy in Israel

Chemotherapy is the main treatment for secondary liver cancer. Sometimes it is given before surgery to increase the efficiency of operations.

The choice of drugs will be due to the localization of primary focus of the disease. For example, if it was breast cancer that has spread to the liver, appoint cytostatics, intended for the treatment of breast cancer .

Unfortunately, chemotherapy is not completely cure the disease, but it may slow or stop its development, reduce symptoms.

This type of treatment used to reduce the metastatic tumors in the liver to remove them surgically and called neoadjuvant therapy. Also, in some cases carried out after surgery to prevent recurrence, referring to adjuvant therapy.

Chemotherapeutic drugs are sometimes prescribed in tablet form, but more often given intravenously in a hospital outpatient department, in this case may require hospitalization within a few days.

This type of treatment is usually carried out in cycles, should rest for two or three weeks after therapy. This allows the body to recover from any adverse effects of treatment. The number of treatment periods affected by the type of cancer, as well as the body's response to treatment.

Very rarely appointed intraarterial chemotherapy into the hepatic artery supplying blood to the body. Drugs are delivered directly to the tumor. This specialized equipment, which can be prohibitive for most hospitals. Alternative method - chemoembolization.

Side effects

Chemotherapy can sometimes cause unpleasant effects of treatment, they can often be controlled with medication - to avoid or reduce.

  1. the risk of infection. This type of therapy reduces the number of white blood cells, which fight infection. This condition is called neutropenia. Develops seven days after initiation of chemotherapy and continued for two weeks after its completion. Then, the number of white blood cells steadily increases and returns to the normal state until the next treatment cycle. To check the number of white blood cells is assigned to a blood test.
  2. Hematomas and bleeding occur due to decreased production of platelets by the action of body therapy.
  3. Anemia - reduces the number of red blood cells carry oxygen to the body. As a result of developing fatigue, difficulty with breathing. At too low a blood transfusion may be necessary to red blood cells.
  4. Nausea and vomiting - symptoms, which are struggling with using antiemetic drugs to prevent or greatly reduce the symptoms. If you do not help some medicines prescribed other.
  5. Painful sensations in the mouth. There may be a dry, form small ulcers during treatment. Reduces the risk of excessive drinking, regular accurate teeth cleaning with a soft brush. When the problems encountered can prescribe a gargle and drugs that prevent the risk of infections or purified from their mouth.
  6. Changes in taste, it will be held after the end of therapy. Nutritionist recommend ways of dealing with this side effect.
  7. Hair loss - a temporary consequence of the treatment, after the completion of which can change the structure of hair: they will become more curly or straight, thinner, or change color.
  8. Peripheral neuropathy. Developing numbness or tingling in arms or legs due to the effect of some chemotherapy drugs on the nerves. These symptoms can be controlled by slightly lowering the dose of the drug. Improvements usually occur slowly, it takes several months after treatment. In some cases, these symptoms become permanent.
  9. Fatigue - a common side effect that is enhanced especially by the end of chemotherapy, and for several weeks afterwards.

Duration of embolisation from 90 minutes to two hours. Usually requires overnight hospitalization.

For complex cases of a decision on the program of treatment shall be adopted after consideration by the council of physicians using an interdisciplinary approach. Its advantages include access to all the experts and a comprehensive assessment of the situation. The team may include surgeons, transplant surgeons, oncologists, radiologists, hepatology, gastroenterology, pathology.

Treatment of metastases in the liver - Operations in Israel

Resection of liver is a serious operation which takes 3 to 7 hours. It is carried out in specialized hospitals, doctors are known as hepatobiliary surgeons. This type of treatment is only suitable for some patients with secondary liver cancer. Usually there are no long-term side effects after liver resection, because the rest of the body segments can grow for several months after surgery and to perform all its functions normally.

Chemotherapy is performed to shrink the tumor before surgery, thus increasing the efficiency and safety of surgery, or after surgery to reduce the risk of cancer returning.

Liver transplant operation , when the organ was removed and replaced are not used in the secondary treatment of liver cancer due to the high risk of relapse. It is receiving an immunosuppressant that are assigned to the body does not reject the transplanted liver.

Embolization of portal vein in the treatment of liver metastases

With this method increases the putative pre segment remaining liver parenchyma after resection on average 8-16%. The main purpose - to prevent the development of liver failure.

The indications for liver resection is a procedure. Implemented in hypochondrium puncture, into the portal vein of the liver embolizing substance is administered (microparticles, spirals etc.), Which blocks the vessel, causing compensatory growth remaining stake body.

The procedure is performed in the X-ray department, ultrasound is used, apply a local anesthetic to control. The duration

Staged liver resection

The removal process is carried out in two stages. One segment resected during the first operation, the second - after a few weeks when the body size increases.

One of the features of the Israeli medicine - specialization of doctors in a particular area, where he became a professional very high level.

Survival rate of patients with cancer in Israel - the highest in the world.

Laparoscopic surgery in the treatment of liver metastases in Israel

In some situations, there is a possibility of laparoscopic surgery to remove the affected part of the liver. Performed several small holes instead of one of the recessed section. Typically, three small incision and one - the higher value near the navel and use it to remove the affected part of the liver.

The surgeon uses a tool known as a laparoscope (thin tube with an eyepiece at one end and the other camera), through which sees the inner surface of the abdominal cavity. It is placed inside through a small incision.

The main advantages of this type of surgery: damage is not as significant as compared to open surgery, less pain and shorter recovery time. It requires surgeons with special training and experience in the use of laparoscopic techniques to perform such operations.

After operation

A patient brought to the intensive care unit or intensive care units, where it stays for about 24 hours. The incision is placed drainage tube, which departs seroma and blood. Nutrients and fluids enter the body via intravenous infusion for a few days until the patient can not independently eating and drinking. The bladder catheter to drain urine is removed and later, as the patient's recovery.

To eliminate the pain and discomfort after surgery prescribed painkillers, at first it may be in the form of injectable morphine. Another method is epidural anesthesia.

If there is such a symptom like vomiting, prescribe anti-emetics.

Typically, the period of hospitalization can be from 4 to 8 days. For a number of weeks, it is likely to require admission painkillers. It may take up to six months before a patient begins to return to normal life.

Despite the fact that the cancer had metastasized in the body, modern methods of oncological treatment in Israel are not only able to stop tumor growth, but also lead to its regression. They significantly prolong the life of patients and reduce their suffering.

Radiofrequency ablation in the treatment of liver metastases in Israel

Radio frequency ablation (RFA) uses radio waves to destroy cancer cells by heating them to high temperatures. It may be applied after the operation, and to - to reduce tumor size.

During the procedure used sedatives, local anesthesia, sometimes - general anesthesia. To control the operation applied CT or ultrasound, fine needle is introduced into the central portion of each tumor. Through them to the homes of the radio waves are transmitted, they heat the cancer cells and destroy them.

Duration of treatment is about 30 minutes. It may designate for the treatment of malignant tumors up to 5 cm in diameter. Several hours later, the patient is able to leave the clinic.

Side effects include bleeding, so it may need a blood transfusion. It is rarely applied in step damage the gallbladder or bile ducts.

Radiofrequency-Assisted Surgery

In many ways, this method is similar to radiofrequency ablation, also using radio waves. One object of this operation is to attempt to reduce the amount of bleeding, which sometimes occur after a standard surgery. Heating of tissue seals the blood vessels and helps to stop the flow of blood.

Hormone therapy in the treatment of liver metastases in Israel

Hormone therapy is sometimes used for the treatment of secondary liver cancer, generally if the initial focus was the mammary gland.

This type of drug may designate, to try to slow the growth of cancer cells and improve symptoms.

Targeted therapy of secondary liver cancer

Targeted therapy is the treatment, the effect of which is directed to the specific proteins located either on the surface of malignant cells or inside it.

There are several different types of targeted therapy. The choice will depend on where the initial focus of the tumor.

Monoclonal antibodies in the treatment of liver metastases in Israel

Monoclonal antibodies - are drugs that recognize certain proteins (receptors) on the surface of cancer cells. Antibodies act on the receptor and, depending on the active ingredient using various methods destroy abnormal cells. Some - stopping the formation of new blood vessels, the other - to stimulate the body's immune system to attack the disease.

Certain types of cancer, which gave liver metastases, can be treated with monoclonal antibodies.

  1. Trastuzumab (Herceptin) is used in primary breast cancer, sometimes - gastric cancer.
  2. Cetuximab (Erbitux®) - in primary intestinal cancer, in some cases, can be combined with chemotherapy.
  3. Bevacizumab (Avastin®), panitumumab (Vektibiks®) - in primary intestinal cancer.

Inhibitors of tumor growth in the treatment of secondary liver cancer

In order to grow and divide, the cancer cells must "talk" to each other using chemical signals. tumor growth inhibitors interfere with this process and, therefore, affect the ability of the cancer to develop. In clinical trials using the drug gefitinib (Iressa®) in the treatment of tumors, which was the primary focus in the lung.

Other treatments for liver metastases in Israel

These therapies can be administered in combination with chemotherapy and / or surgery. They are available only in some specialized hospitals.

Laser ablation in the treatment of secondary liver cancer

The technique is similar to radiofrequency ablation, but uses laser energy instead of radio waves. Cancerous cells destroy by heating.

Used sedatives, local anesthesia, in rare cases - general anesthesia. Laser using a thin flexible tube - the doctor inserts the endoscope into the liver, the central part of the tumor under ultrasound or CT. The radiation heats the tumor and destroys it.

Duration of treatment is about 10-15 minutes. It is used to treat tumors up to 5 cm in diameter. Typically, after a few hours, the patient is able to leave the clinic.

Side effects of treatment include pain and high temperature (fever) in a short time.

Cryotherapy / cryosurgery in the treatment of liver metastases

During cryotherapy device called cryoprobe is placed in the central part of malignancy. Gavage liquid nitrogen is passed. He freezes and destroys cancer cells. the treatment area is sometimes given time - 10-15 minutes to thaw, then freeze again.

Cryotherapy is suitable only for liver tumors less than 4 cm procedure takes 30-60 minutes and usually requires a short stay in the ICU, and then about two days -. In a dedicated compartment of liver treatment.

Selective Internal Radiation Therapy (SIRT)

This treatment method involves administration of microspheres to the liver, which are coated with a radioactive isotope which emits a certain dose of radiation for several days.

First performed an angiogram, which examines blood flow in the liver, to make sure that in the course of therapy, the microspheres are not going anywhere for the body limits.

Further, for the most proper treatment procedures performed an angiogram. The microspheres are administered through the catheter, and control their placement in small blood vessels surrounding the tumor.

Emits radiation damages the cancer cells by stopping their growth, as well as the blood vessels that feed the tumor. the amount of radiation - not enough, its effect lasts for about 10-14 days. The microspheres remain in the liver, they are not removed, they are harmless.

Treatment involves a stay in the hospital for 1-4 days.

Side effects include fever and abdominal pain immediately after the injection. Other undesirable effects include nausea, vomiting, diarrhea.

Depending on the effectiveness of therapy procedure can sometimes be repeated.

Microwave ablation in the treatment of liver metastases

This treatment destroys cancer using heat. Needle electrodes were placed into the tumor under local or general anesthesia. Cancer cells are destroyed by microwave radiation. This innovative treatment, and while scientists continue to study its use and effectiveness.

Ethanol injection in the treatment of secondary liver cancer in Israel

This method uses ethanol therapy to destroy cancer cells. Equipment is only suitable for small tumors (4-5 cm). Under ultrasound or CT scan using a local anesthetic is administered directly into the tumor alcohol injection. The indication for treatment is a single small tumor or a small number of individual tumors. If necessary, treatment is repeated.

Chemoembolization in the treatment of liver metastases

Under ultrasound catheter is inserted into a blood vessel in the groin area and advance it to the hepatic artery. Then administered a chemotherapeutic agent, mixed with a special oily liquid, and the catheter is removed. Chemoembolization is usually performed under local anesthesia.

The oleaginous fluid forms clots in the vessels supplying the tumor, stopping the supply of oxygen and nutrients. Cytostatic agent in high concentration in the tumor remains that can kill certain cells and reduce its size.

Duration of treatment and side effects which it causes will depend on the type of medicines.

High Intensity Focused Ultrasound HIFU

This new method of treatment using focused ultrasound to generate heat inside the tumor cells and destroy them. Apply general or local anesthesia.

HIFU indicated for the treatment of secondary liver cancer when there are contraindications for surgery. Use it to control the cancer.

Side effects of this therapy are usually mild and include the liver pain, swelling and slight blistering of the skin. You may need a repeat procedure.

Stereotactic radiotherapy

This new method of radiation therapy, which can be used if surgery or RFA are not suitable. Delivered to the tumor radiation doses are very high, but the impact on the surrounding healthy tissue is minimal.

prices for treatment

The cost of diagnosis and treatment in Israel, cheaper than in Europe or the US and clinics. Pre-screening program in this disease include:

  1. Admission oncologist - 610 dollars.
  2. Blood tests - 550 dollars.
  3. blood test for tumor markers - $ 250.
  4. Revision material - 670 dollars.
  5. PET - CT - 1680 dollars.

Total amount: 3730 USD.

Diagnostics shows the spread of metastasis at a secondary cancer, you can assign additional procedures as appropriate:

  1. US - 320 dollars.
  2. MRI of the body - in 1470 dollars.

Cost therapeutic approaches (conservative therapy) is in the following range:

  1. Chemotherapy - 1180 dollars. (One session).
  2. Preparations for the chemotherapy - 360 dollars.
  3. Radiofrequency ablation - 35,270 dollars.

Prices for surgery:

  1. Liver resection (partial deletion) - 56 $ 220.
  2. Liver transplantation - 200 thousand dollars.
  3. Pancreatoduodenectomy - 51 100 dollars.

Chance of recovery there is in each patient. Thanks to more affordable prices for treatment in Israel is going more and more patients from Russia and CIS countries. Organize diagnosis and treatment in the short term will help our company. Find the information you need by sending a request at the site.

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