chemotherapy for pancreatic cancerChemotherapy uses in the fight with cancer cytostatics. Usually it involve in the treatment of pancreatic cancer in Israel. A team of doctors to work with patients in the planning process - the choice of drugs, dosage chemotherapy schedule - takes into account the individual characteristics of each patient. Also, other treatments may be involved.

For most patients, an oncologist is the main doctor. Oncologists in Israeli hospitals specialize in the diagnosis of cancer, to chemotherapy, immunotherapy, targeted therapy. They work closely with the patient and the rest of the team of doctors choose treatment options cytostatic agents, based on the individual characteristics and needs of the body. Oncologists strive to find the right chemotherapy drug or a combination thereof for each patient. For this purpose, used specific tests, such as molecular profiling of tumor to select a suitable combination of drugs and reduce the level of potential toxicity.

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Chemotherapy for pancreatic cancer in Israel

If chemotherapy is becoming part of the overall treatment plan, the oncologist coordinates the entire process, the dose and schedule. Implements performance control, making changes as required.

Chemotherapy for pancreatic cancer is prescribed:

  • as the main treatment for inoperable (locally advanced or metastatic) cancer ;
  • with the aim to ease the pain symptoms and monitor cancer at later stages;
  • after surgery, to rid the body of remaining malignant cells, as well as to reduce the likelihood of recurrence;
  • in order to reduce the size of the tumor before surgery or irradiation.

Usually chemotherapy for pancreatic cancer is systemic, which means that the spread of drugs through the bloodstream throughout the body and destruction of malignant cells.

Sometimes, treatment with cytostatics administered at the same time as radiotherapy. This treatment is called chemoradiotherapy.

Certain cytotoxic agents given in the form of tablets, but most of it goes into the body intravenously. For this purpose, a dropper, a central catheter, PICC line system (central venous catheter that is implanted).

Certain chemotherapy drugs enter the body continuously with a small portable pump that is attached to the central catheter, or PICC line system. A controlled amount of medicine into the bloodstream for a predetermined time. This makes it possible to receive treatment on an outpatient basis, and less time to be in the clinic.

No matter what form of medication comes into the body in the form of tablets or intravenously, they are absorbed into the bloodstream and spread throughout the body, destroying cancer cells wherever they are.

Chemotherapy for pancreatic cancer usually involves multiple sessions. After each procedure should be a period of rest for a few weeks, so the body can recover, as this type of treatment causes a particular adverse effect on the body. Period of therapy and recovery cycle. The amount used is determined by the latter drugs, the body response to treatment. Most cytotoxic drugs patients receive outpatient.

chemotherapy drugs for cancer of the pancreas in Israel

During this type of cancer treatment using these kinds of cytostatic drugs and combinations thereof:

  • gemcitabine (Gemzar);
  • 5-fluorouracil (5-Fu);
  • 5-fluorouracil and leucovorin;
  • 5-fluorouracil and cisplatin (Paraplatin rr);
  • 5-fluorouracil, irinotecan (Camptosar) and oxaliplatin (Eloxatin);
  • FOLFIRINOX - leucovorin, 5-fluorouracil, irinotecan, and oxaliplatin;
  • gemcitabine and cisplatin;
  • gemcitabine and paclitaxel (Abraxane).

If there is no reaction to some drugs, others may be used.

chemoradiotherapy

At the same time the patient receives chemotherapy and radiation. This increases the effectiveness of therapy in general. Chemoradiotherapy may recommend after surgery , before surgery or as the main treatment for locally advanced tumors. The most frequently used drug, 5-fluorouracil.

Chemotherapy for pancreatic cancer after surgery

The duration of this treatment is usually about six months. The most commonly used gemcitabine is administered intravenously over 30 minutes. The therapy is carried out 1 day a week for 21 days followed by rest every fourth week. These four weeks up cycle, and is generally assigned cycle 6 of treatment.

Also after the operation applied fluorouracil (5-FU) administered intravenously. Sometimes it is recommended tablet form fluorouracil called capecitabine.

Chemotherapy for advanced pancreatic cancer in Israel

Most often recommended gemcitabine. Sometimes prescribed combination of three chemotherapy drugs - FOLFIRINOX, which constitute folic acid (leucovorin), fluorouracil (5-FU), irinotecan, and oxaliplatin.

According to the results of their study it found that FOLFIRINOX scheme is more effective in the treatment of locally advanced and advanced pancreatic cancer than the standard gemcitabine therapy. Nevertheless, folfirinox causes much more severe side effects than gemcitabine, therefore only suitable for patients who are in good general health and are able to cope with the adverse effects of therapy.

As appointed FOLFIRINOX?

Each treatment cycle lasts for two weeks. On the first day of each cycle the patient receives folic acid, 5-FU, irinotecan and oxaliplatin intravenously. After that, the nurse establishes a portable pump to the PICC line system or a central catheter, and the patient can leave the clinic. With the pump body is continuously fed 5FU over the next two days. Followed by a rest for 11 days. It can be assigned to 12 treatment cycles for about six months.

They may also be other combinations of drugs, in some cases as part of clinical trials. The Israeli medical center conducts research targeted therapies aimed at improving the effectiveness of the treatment.

If there are metastases in the liver , and sometimes involve intra-arterial chemotherapy. Cytotoxic agents act directly at a malignancy, located in the liver. Thus, the abnormal cells are destroyed, and minimizing damage to healthy tissue.

Chemotherapy neuroendocrine tumors

cytostatics treatment of these types of tumors are rarely used. In general, combinations of two or more chemotherapeutic agents.

The most frequently prescribed adriamycin and zanozar. Some people recommend Doxil - doxorubicin liposomal form. The drug has a lipid envelope, whereby side effects are reduced.

Applied as other cytostatic agents: fluorouracil (5-FU), detitsen, temozolomide (Temodar®). Recent studies have shown the effectiveness of the combination of temozolomide and thalidomide or temozolomide and capecitabine.

Potential side effects of chemotherapy pancreatic cancer

Cytotoxic agents may provoke some undesirable consequences, but at the same time to improve health, alleviate the symptoms caused by the disease. Most patients experience some of the effects of treatment, but they are successfully controlled in the medical centers of Israel by means of drugs. They usually go away after the end of therapy.

A team of doctors working with patients using a variety of modern techniques to prevent or control the adverse effects of chemotherapy for pancreatic cancer. For example, before the treatment with cytostatics may be prescribed medicines, which would smooth acute manifestations.

The treatment program, in which using multiple chemotherapeutic agents, leads to a more serious side effects than the use of drugs.

The doctor will inform the patient in an Israeli hospital, what to expect from treatment. Below are the main adverse effects, as well as some methods for their reduction and control.

The probability of infection

cytostatic treatment reduces the number of white blood cells that help the body fight infection. Their reduced level (neutropenia) increases the tendency to infections. Be sure to consult a doctor if the following symptoms: sore throat, cough, frequent urination, diarrhea; chills; general malaise; elevated body temperature (more than 37.5).

For the treatment of infections prescribe antibiotics. Before the course of cytostatic agents take a blood test to check for normal levels of white blood cells. Sometimes chemotherapy in pancreatic cancer put off, if their content is low.

Inflammation in the mouth

This condition is caused by some chemotherapy drugs. Drinking plenty of fluids, proper care will benefit. The physician may prescribe mouthwashes and medicines for the prevention and treatment of infection.

Diarrhea

Chemotherapy for pancreatic cancer often causes this symptom. It is generally well controlled by drugs. However, the use FOLFIRINOX circuit causes more severe diarrhea. It is important to drink plenty of fluids.

Malaise (nausea), emesis

Some chemotherapy drugs can cause these symptoms. To prevent them doctor prescribes anti-emetics. Some cause constipation, so it is important to inform the doctor if there is a problem.

Hair loss

Gemcitabine and froruratsil in rare cases lead to hair thinning. Their loss is more common if you are using FOLFIRINOX scheme. Hair grow back after treatment ends. The doctor will give recommendations on how to deal with this problem.

Change skin

Cytotoxic drugs can cause rashes, skin dryness and itching. As needed the doctor will prescribe medication to facilitate state.

In the course of chemotherapy for pancreatic cancer and after a few months, the skin will be very sensitive to the sun, so you can burn to get much easier than usual. It will be important to use a cream with a high sun protection factor (SPF 30 or higher), as well as to cover the open spaces of clothing and a hat.

Pain in the hands and feet (hand-foot syndrome)

For some people, treatment of fluorouracil (5-FU) or capecitabine may cause redness, dryness and pain palms of the hands and soles of the feet. Condition gets better when the treatment ends.

Numbness or tingling in the hands or feet (neuropathy)

Oxaliplatin (a drug used in FOLFIRINOX) can cause these symptoms. The patient becomes difficult to handle small objects. Condition improved after treatment. But some people have tingling and numbness may persist for several months.

Most of the undesirable effects of chemotherapy in pancreatic cancer are temporary and disappear after its completion.

Israeli doctors use several chemotherapy protocols and practice evidence-based medicine. In some cases, involve innovation, as the world and belonging to Israeli scientists.

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