Cervical cancer typescervix - the lower is the narrowed portion of the uterus that connects the uterus with the vagina. Cervical cancer is called malignant tumor resulting from abnormal cell division, of the organ.

Types of cervical cancer:

  • Squamous cell carcinoma.
  • Pezervnogenny cancer.

According to various reports, cancer education in the cervix in second or third place among all types of cancer in women. The cervix is ​​an important segment of the human reproductive system. Therefore, the study of its diseases are allocated huge amounts of money in the world's best hospitals. Excellent results demonstrate the treatment of cervical cancer in Israel.

If you are diagnosed with cervical cancer, our center «Tlv.Hospital» will help in the organization of high-quality treatment in Israel for a short time, leading physicians, in a comfortable environment and at a minimal cost. Treatment of cervical cancer in Israel is successfully engaged inJacob Cohen and others.

Causes of cervical cancer

Modern medicine stresses clear correlation between the presence in the patient of human papillomavirus (HPV) and the occurrence of malignant cells in the cervix. In addition you can allocate a number of factors that increase the risk of cervical cancer:

  • Pregnancy at an early age (younger than 17 years);
  • lack of fruit and vegetables in the diet;
  • nevynoshennyh three more pregnancies;
  • Chlamydia infection;
  • genetic predisposition;
  • smoking;
  • prolonged use of birth control pills;
  • hormonal disruptions in the body;
  • promiscuous.

Cervical cancer usually develops slowly. In the early stages of the disease almost anything itself does not give out. Over time, they begin to show symptoms listed below for cervical cancer:

  • pain in the pelvic area;
  • bleeding between periods of the menstrual cycle;
  • bleeding after intercourse;
  • weakness;
  • anemia;
  • unreasonable weight loss;
  • malfunctions mochevyvoditelnoy system;
  • profuse watery discharge, etc.

In the early stages of cancer extremely well to treatment. Annual checkups at the gynecologist allow time to identify the disease and to conduct high-quality treatment. Confirm the diagnosis can only be a specialist oncologist after a series of tests. One of the best - acancer treatment in Israel. It is a high quality and more affordable than in other developed countries.

Diagnosis of cervical cancer in Israel

Top Israeli clinic of great importance give quality diagnosis. After all, on whether the diagnosis is reliable, it depends on the adequacy of the subsequent course of treatment. Israel's hospitals are very well equipped for all kinds of tests and studies for cervical cancer. Integrated diagnostics for cervical cancer consists of the following list of techniques:

  • consultation and examination of the expert;
  • lab tests;
  • biopsy;
  • MRI and PET-CT;
  • vaginal ultrasound;
  • CT scan;
  • colposcopy etc.

Complete diagnosis of cervical cancer in Israeli medical centers usually takes a maximum of 5 days. After that the doctor prescribes an individual treatment program for each patient. Tlv.Hospital Counseling Center - your reliable partner in the organization oftreatment in Israel .

Methods of treatment of cervical cancer in Israeltreatments for cervical cancer

The optimum treatment program is based on the diagnostic data. Treatment in Israel is selected depending on the type of tumor, its location, the presence of metastases, status of the patient's health, age and other relevant factors. For the treatment of cervical cancer using modern effective techniques and ultra-precise high-tech equipment. Traditionally, the following therapies: surgery, radiation therapy and chemotherapy.

Surgical treatment of cervical cancer in Israel

Surgery is used during the initial stages of the disease treatment. The choice of the operation affect the volume of the tumor and its spread.

The operation may be followed by complete or partial removal of the uterus (trachelectomy, hysterectomy). There are several types of surgical treatment of cancer of the cervix tumors:

  • knife amputation;
  • laser surgery;
  • Supersonic soundings surgery;
  • radiosurgical method;
  • cryoablation of cancerous cells in the cervix;
  • conical electroexcision.

In the early stages of the disease using three types of surgical procedures:

  • cone biopsy;
  • hysterectomy;
  • trachelectomy radical.

The conical cone biopsy involves removing a sample of cervical tissue. It is performed when the cancer cells in a small amount of body penetrated the border.

Hysterectomy (hysterectomy) - surgery to remove the uterus. There are two types - a total and radical.

total hysterectomy

During surgery, the surgeon removes the uterus and cervix, and sometimes the lymph nodes of the pelvis. If a woman has reached menopause (and sometimes before this period) are extracted fallopian tubes and ovaries. This operation for cervical cancer - only suitable option for the early phases of the disease - 1A1 and 1A2.

radical hysterectomy

This type of surgery in the treatment of cervical cancer in Israel involves removal of the uterus, cervix, adjacent tissues (parameter), the fallopian tubes, the lymph nodes of the pelvis and upper part of the vagina. Sometimes the ovaries removed and abdominal lymph nodes.

Whenever possible, keep the ovaries in young women. Since their removal leads to early menopause.

Hysterectomy can spend using cavity approach (abdominal hysterectomy) or laparoscopic.

laparoscopic hysterectomy

The operation in the treatment of cervical cancer in Israel is carried out under general anesthesia. The surgeon performs several sections of small size in the abdominal cavity, enters through these special tools and a laparoscope. Uterus, cervix and ovaries (if necessary) is removed through the vagina or a small incision in the abdomen.

radical trachelectomy

If the patient wants to have a baby, this operation for cervical cancer can be offered. It is carried out only in the initial phases of the disease. The uterus is conserved, respectively, the ability to have a baby in the future.

The surgeon removes the cervix, the surrounding tissue and the upper segment of the vagina. They can be resected lymph nodes of the pelvis, as a rule, during laparoscopic surgery.

After this procedure, there is a high risk of miscarriage. If a woman to bear a child, it will be necessary to give birth by caesarean section.

Radical trachelectomy performed in only a few hospitals in Israel.

Prior to surgery for cervical cancer

Conduct surgery is preceded by a series of tests. They performed a few days or even weeks. A member of the surgical team will discuss with the patient the operation. meeting with the anesthesiologist will be assigned.

Woman will give special elastic stockings to be worn during and after surgery for cervical cancer to prevent the formation of blood clots in the legs. If you have any questions or concerns, you should discuss them with your surgeon.

If the patient smokes, it is important to quit or reduce smoking prior to surgery. This will reduce the risk of infections, speed up the healing process.

Program of recovery after surgical treatment of cervical cancer in Israel

A number of Israeli clinics offer enhanced recovery program. They reduce the likelihood of adverse events after surgery for cervical cancer and shorten the recovery period.

Such a program requires careful planning of the surgical process. This is important, inter alia, that the patient has been properly prepared. Doctors suggest high-calorie and protein supplements before and after surgery. a woman will also be encouraged to start moving as soon as possible after surgery. If prescribed bed rest, recommend specific exercises for the legs and breath.

The nurse closely monitors the drips, drains, changing bandages. A few days the patient will feel some pain or discomfort, but pain medication will provide the necessary assistance.

After a hysterectomy or trachelectomy marked vaginal discharge to six weeks. It is recommended to avoid use tampons and have sex at this time.

It should refrain from serious physical activity during the three months after abdominal operations and up to 1.5 months after laparoscopy.

Some women need more time to recover from the surgery. Rarely observed long-term complications. After surgery for cervical cancer may have problems with bladder or bowel, swelling of one or both legs.

Radiation therapy for cervical cancer in Israel

Radiotherapy destroys tumor cells by ionizing radiation.

Radiation therapy is carried out:

  1. In the initial stages or in locally advanced cervical cancer.
  2. After surgery, if there is a high risk of the disease returning.
  3. To reduce the symptoms of cancer, such as bleeding.

Irradiation is often given together with cytostatic drugs - chemoradiotherapy.

This type of treatment is given in two ways - both external and internal radiation (brachytherapy). They can be combined. The course lasts 5-8 weeks on average. The doctor who is planning the course, discuss it with the patient.

Radiotherapy affect the ovaries. If a woman has not reached menopause, radiation will have an impact on these bodies, they stop producing eggs and hormones (estrogen and progesterone).

This will trigger an early menopause - after 8-9 weeks after therapy. The woman is no longer able to have children. Despite this, it is required to use contraception during this period, to exclude the possibility of pregnancy.

The doctor in an Israeli hospital will discuss this with the patient before the procedure. In addition, recommendations will be given as to cope with the symptoms of menopause. There will also be given the available options, if a woman wants to have children in the future.

External-beam radiation therapy

It is most often used. This kind of treatment of cervical cancer in Israel - a series of short, daily outpatient procedures in radiotherapy department using equipment that resembles a large X-ray machine.

It uses several different types of linear accelerators, but they all work the same way. To determine the number of treatments affect the treatment of the problem - or cure the disease control her symptoms.

curative radiotherapy

Such treatment of cervical cancer in Israel takes place in the week, every day. It lasts from two to seven weeks. Each session is called a fraction. Therapy in fractions ensures a smaller amount of damage to healthy cells.

Sometimes prescribed more than one faction or the daily exposure every day for 14 days without interruption. Sometimes treatment is given three times a week - for example, on Mondays, Wednesdays and Fridays.

Palliative radiotherapy

Such treatment of cervical cancer in Israel is used in different situations. For example, irradiation provide:

  1. In the area of ​​one or more bones to control the pain, which is caused by the spread of cancer.
  2. In the area of ​​the lungs to reduce cough, provoked by a tumor in the lungs.
  3. To help with bleeding from the lungs, bladder or skin tumor.

Palliative treatment may be one or more treatment sessions - to 10. One or two sessions become a cause of short-term side effects, less serious, such as flu-like symptoms.

brachytherapy

Internal radiation therapy delivers radiation directly to the cervix and the surrounding area. In general it is carried out after external radiotherapy.

Appointment type of brachytherapy depends on whether the uterus was removed. Such treatment of cervical cancer in Israel is carried out using a set of applicators.

endometrial brachytherapy

If the patient did not pass hysterectomy prescribe this type of brachytherapy. The doctor inserts applicators through the vagina, the cervix into the uterus. Sometimes additional applicators are positioned along the neck. This procedure is performed in the operating room under general anesthesia or sedation. Sometimes spinal anesthesia may be used. For urine drainage catheter in the bladder. To protect the rectum and prevent movement of the applicator, set pad of cotton into the vagina.

Applicators may cause discomfort, so you need to intake of painkillers.

intravaginal brachytherapy

If the hysterectomy was performed, a large hollow applicator is placed into the vagina. In this case, it does not require anesthesia or sedation to install it, as well as laying.

How is the treatment?

In order to check the position of the applicator, you need an MRI, CT or X-ray. After that, they connect to the special equipment, which is controlled by a radiologist, delivering radioactive capsule in the applicator. The machine is programmed in such a way that the source emits the correct dose of radiation.

Treatment can be carried out in a hospital or on an outpatient basis. There is a course that provides a high dose of radiation for several minutes is - low for a few days. Brachytherapy with pulsating radiation dose rate provides periodic pulses over a number of days.

Side effects from radiation therapy helps to soften the use of some medications prescribed by your doctor.

Chemotherapeutic treatment of cervical cancer in Israel

This type of treatment in the fight with cancer uses anticancer drugs. Sometimes it is addressed in the treatment of cervical cancer in Israel. Doctors in the planning and selection circuitry, and doses of medicines account for individual characteristics.

Chemotherapy is recommended in the following cases:

  1. As the main form of treatment for cervical cancer in Israel, when the disease was diagnosed for the first time or returning after treatment.
  2. At the same time as radiation therapy to enhance its effectiveness and reduce the risk of the disease returning.
  3. After surgery to get rid of the remaining abnormal cells and to reduce the likelihood of relapse.
  4. Reduce the tumor size prior to use other methods - surgery or radiotherapy.
  5. To control the symptoms of advanced disease and reduce pain.

Drugs, spreading through the bloodstream, reaching lesions throughout the body, including those that could break away from the primary tumor.

In the treatment of cervical cancer following drugs are often used in Israel:

  • cisplatin (Platinol AQ)
  • carboplatin (Paraplatin, Paraplatin AQ)
  • paclitaxel (taxol)
  • topotecan (Hycamtin)
  • gemcitabine (Gemzar)
  • 5-fluorouracil (Adrucil, 5-FU)
  • ifosfamide (IFEX)
  • docetaxel (Taxotere)
  • irinotecan (Camptosar)
  • mitomycin (Mutamycin)
  • vinorelbine (Navelbine)
  • pemetrexed (Alimta)
  • capecitabine (Xeloda)
  • epirubicin (Pharmorubicin)
  • hydroxyurea (Hydrea)
  • Pegylated liposomal form of doxorubicin - Keliks (Caelyx).

The most common chemotherapy drugs schemes for treatment of cervical cancer in Israel:

  • cisplatin and 5-fluorouracil
  • cisplatin and ifosfamide, with / without bleomycin (Blenoxane)
  • cisplatin and paclitaxel, with / without ifosfamide
  • cisplatin and gemcitabine
  • cisplatin, and mitomycin
  • cisplatin and topotecan
  • carboplatin and paclitaxel
  • carboplatin and docetaxel
  • cisplatin and vinorelbine

Chemotherapy may be offered in conjunction with radiation therapy. Cytotoxic agents can make cancer cells more sensitive to radiation. The combination of these methods is more effective than holding them separately.

The most commonly used chemotherapy drug cisplatin, it acts as a radiosensitizer. It is usually given once a week throughout the course of radiotherapy.

Chemoradiotherapy followed by more severe side effects.

Among the potential side effects of chemotherapy action point:

  • vomiting and nausea;
  • loss of appetite;
  • alopecia;
  • stomatitis;
  • fatigue;
  • changes in the skin;
  • reduction in the number of blood cells;
  • diarrhea;
  • joint and muscle pain;
  • allergic reactions;
  • hearing loss;
  • cell damage some organs (heart, kidney, bladder, liver, reproductive organs, nervous system, brain);
  • acute myelogenous leukemia.

Targeted therapy

Targeted therapy is sometimes used in the treatment of cervical cancer in Israel. It uses drugs that target specific molecules which are localized on the surface of cancer cells. These molecules send signals to the cells to begin to grow and divide. Medications stop the development of tumor while limiting negative effects on healthy cells. This method is also called molecular targeted therapy.

Targeted therapy in the treatment of cervical cancer in Israel recommend:

  1. If a relapse occurs.
  2. In the presence of secondary foci of disease in other organs or body parts.

In planning treatment, the choice of drugs, doses and schedules a team of doctors take into account the individual characteristics of each organism used genetic tests to determine the best option.

In most cases, using bevacizumab (Avastin) in cervical cancer. This monoclonal antibody.

One way to fight infections - the creation of antibodies. They help the immune system to recognize infection if the body is exposed to it again and handle quickly. The antibodies can be created in the laboratory and used to treat cancer.

Monoclonal antibody therapy is sometimes called the target, since they act on specific proteins of cancer cells. They destroy cancer:

  • stimulating the immune system to attack the abnormal cells;
  • joining an antitumour drug, or radioactive substances, and delivering it exactly to the cancer cell.

Avastin - monoclonal antibody directed at vascular endothelial growth factor (vegf). VEGF - one of the main protein, which helps to create the blood supply to the tumor. Avastin is attached to a protein, and the tumor can not use it to create and vascular growth.

Bevacizumab also improves the effect of chemotherapy, delivering drugs directly to the tumor. The drug is sometimes used alone and sometimes with cisplatin or carboplatin and paclitaxel for the treatment of metastatic or recurrent cervical cancer.

The most common cervical cancer in Israel is treated by a combination of several kinds of therapy. So can achieve the maximum effectiveness of the treatment of the disease.

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