Symptoms of Ovarian CancerOvarian cancer is less common disease among the "female" types of cancer, compared with breast cancer and uterine cancer. According to some reports, he ranked seventh in the list of cancer in women. However, this does not make it less dangerous. In contrast, ovarian cancer is developing very rapidly and starts metostazirovat. Most tumor is formed on the body surface, at least inside. From the quality of the treatment of malignant tumors in the ovaries depends the life and health of the patient. Because many people prefer to treatment of ovarian cancer in Israel.

If you need a high-quality and effective health care center «Tlv.Hospital» will help to solve this problem. Our company provides services in the field ofmedical tourism in Israel .

We will promptly arrange We for your medical care from the best doctors such as Jacob Cohen , the most comfortable conditions of stay in the country, reasonable prices.

The causes of ovarian cancer

Because ovarian cancer itself does not detect in the early stages of development, it is considered a very insidious disease. It is difficult to give exact causes of cancers in the ovaries. However, the woman must undergo an annual examination of the body, if it falls into a risk group.

  • Mammary cancer.
  • intestinal oncology.
  • Hereditary factor.
  • Nulliparous women.
  • Age over 50 years.
  • Long-term use of hormones.

Symptoms of Ovarian Cancer

As mentioned, if you need treatment for ovarian cancer, Israel is one of the first countries where to go for help. And to make it desirable as early as possible. It is important to understand that ovarian oncology can often be taken for human bladder disease, inflammation of the ovaries, a disorder of the gastrointestinal tract, etc. Here is a list of symptoms, prolonged and aggravated by the manifestation of which is the reason for the passage of screening for ovarian cancer.

  • A feeling of fullness, bloating.
  • Pain in the pelvis.
  • Sharp jumps unexplainable weight.
  • Nausea, decreased appetite.
  • General weakness.
  • Frequent urination.
  • Violation of the chair, blood in the stool.
  • Painful intercourse.

If you have a suspicion of ovarian cancer, it is still not a sentence. Oncology treatment in Israelhas reached an excellent level. On the diagnosis and treatment of cancer you consult the specialists of medical service en.thebestmedic.com.

Diagnosis of ovarian cancer in Israel

Ovarian cancer is diagnosed in Israel, very precisely, with ultra-modern equipment. Managers Advisory Center en.thebestmedic.com organize your transfer to the examination and treatment in the best clinics of Israel. There experienced doctors perform all the necessary manipulations for an accurate diagnosis. The following types of surveys are used for the diagnosis of ovarian cancer:

  1. Examination by a gynecologist (investigate the uterus, ovaries, vagina, bladder and rectum).
  2. Laboratory blood tests.
  3. Biopsy.
  4. Ultrasound Doppler.
  5. MRI, CT, PET-CT.
  6. X-ray.

Treatment of ovarian cancer in IsraelTreatment of ovarian cancer in Israel

When it comes to cancer treatment in Israelinvolves a combination of several effective techniques. In most cases,the surgical removal of malignancy followed by radiation therapy and chemotherapy. By important is to It bear in yet Mind That the program of treatment of ovarian cancer in of Israel is the Adapted to the patient's willingness to or unwillingness to have children the after treatment. Also, it takes into account the stage of tumor development, the woman's age, her health condition and other factors. Good results demonstrate integrated approaches to treatment, including radiotherapy and biological treatment with this medicine Avastin, which blocks the spread of the tumor in the body.

Israeli clinic is used to treat high-tech, efficient methods and quality products. All this combined with the professionalism of doctors helps overcome cancer once and for all.

Israeli clinic successfully treat benign ovarian tumors. Constantly researching new and more sophisticated methods of treatment of ovarian cancer, including at the molecular and genetic level.

Radiation therapy of ovarian cancer in Israel

Radiation therapy, also known as radiotherapy, is not a common treatment for ovarian cancer. This is due to the fact that the disease is often diagnosed at later stages, when oncology spreads into the abdominal cavity.

To be effective radiotherapy should cover all the malignant cells in the radiation field, and gastrointestinal organs such as the liver, kidneys and small intestine are not always able to withstand the radiation dose required to kill tumor tissue. But if the cancer is confined to one or two ovaries without spreading to other organs or pelvic lymph nodes, radiation is considered as an option for treatment.

Radiotherapy in the treatment of ovarian cancer in Israel is recommended:

  • after surgery for destroying malignant preserved segments;
  • under microscopic signs of disease;
  • to relieve pain and control the symptoms of the disease.

Historically, this method of treatment of ovarian cancer at a preferred germ cell tumors. Currently, however, it became known that chemotherapy can cure a percentage of patients with this type of cancer.

Radiotherapy uses in cancer control high-energy, ionizing radiation (eg, gamma rays), which can be delivered in two ways: using a linear accelerator and by injection of radioactive chemicals into the abdominal cavity.

Due to the fact that malignant cells proliferate more rapidly than most healthy cells, they are particularly vulnerable to radiation, which prevents the fission process and the formation of DNA. However, in the body there are fabrics that also divide rapidly (mucous membrane of the digestive tract, hair, skin), so they are particularly vulnerable to radiation therapy.

Side effects of internal radiation therapy include abdominal pain, inflammation of the peritoneum, nausea, diarrhea, formation of adhesions, obstruction of the small intestine, reducing the blood parameters. Possible complications outdoor exposure include irritation and darkening of the skin in the treatment area, swelling.

The operation is usually the first step in the treatment of ovarian cancer. It is therefore very important that the surgeon had high qualifications and experience. Studies show that patients with this diagnosis have better results and a high chance of survival if the maximum amount of the tumor has been removed.

Options for the treatment of ovarian cancer in Israel

Treatment of ovarian cancer in IsraelStage 1 epithelial cancer

Only 15% of cases are diagnosed with this stage of disease. If a woman does not plan more than childbirth, surgery is recommended. Surgery involves a total hysterectomy, which involves removal of the uterus, fallopian tubes, ovaries, execution omentektomii (adipose tissue) and lymphadenectomy (resection of one or more nodes).

Modified surgery, leaving bodies not affected by cancerous process can be recommended for women who plan to have children, if the tumor is limited, and the opposite wedge biopsy of an ovary revealed no evidence of disease. This procedure carries an increased risk of relapse, so total hysterectomy and salpingo-oophorectomy is recommended immediately after the childbirth process. As an additional treatment of ovarian cancer is conducted by:

  1. Irradiation combined with chemotherapy.
  2. Chemotherapy (cytostatic combinations).
  3. Participation in clinical trials.

Some studies support the lower risk of systemic chemotherapy compared with radiation, especially if the lymph nodes have been removed in the abdominal cavity. Despite the fact that radiation therapy can reduce the relapse rate in the pelvic area, the return rate of the disease in other areas remains unchanged, overall survival has no effect.

Stage 1 germ cell cancer

Germ cell tumors develop from germ cells that give rise to eggs and are usually benign. For the most part they are developing in women younger than 30 years.

When dysgerminoma (most common type of germ cell tumors, representing almost half of all cases) of ovarian cancer treatment begins with unilateral removal of the uterus - ovary and fallopian tube appropriate. Adjuvant therapy for these patients may include subsequent radiation or chemotherapy, if a woman wants to have children in the future.

When negerminogennyh tumors (embryonal carcinoma, immature teratoma, choriocarcinoma or mixed germ cell tumors), ovarian cancer therapy involves surgery (unilateral salpingo-oophorectomy) with (without) subsequent chemotherapy or participating in clinical trials of new schemes chemotherapy.

In an Israeli hospital with the patient has a team of leading experts interested in is to provide the best chance of successful treatment with the least adverse effect on the body. Involved innovative methods of therapy for ovarian cancer, including targeted therapy. Physicians have great experience in the treatment of any type of ovarian cancer, including rare species of this disease.

Stromal ovarian tumors (all stages)

They are extremely rare, so there is no standard treatment. Granulosa tumors often respond well to therapy in younger women, while in patients older than 40 years, they can be more aggressive and be difficult to control. But in most cases, surgery is performed to remove as much tumor tissue.

Malignancies of Sertoli-cells Leydinga often developed on one side only, so if the patient is young and the disease is detected at an early stage (for example 1A), the doctor may recommend surgery to remove the modified only ovarian tumor and uterine tube on the same side.

Older women, as well as in the later stages of the disease or bilateral lesions performed major surgery, in which the resected uterus, appendages, omentum, lymph nodes.

If stromal tumors malignant, metastatic and / or have a tendency to relapse, may be useful combination chemotherapy, particularly platinum-based drugs - cisplatin / vinblastine / bleomycin.

There are several conclusions about the appropriateness of radiation therapy for this type of tumor. Current studies show that hormone therapy may have a future in the control of stromal tumors.

Stage 2 epithelial cancer

As an initial treatment of ovarian cancer offered surgery - total hysterectomy, bilateral salpingo-oophorectomy, gland, lymph node dissection.

After surgery, chemotherapy may be recommended in conjunction with or without radiation, as well as participation in clinical trials.

To evaluate the advantages and disadvantages of chemotherapy researchers separated epithelial cancer patients at stages 1 and 2 in a "favorable" and "unfavorable" group.

"A favorable group" has the following characteristics:

  1. disease growth limited to one or two ovaries.
  2. ovarian capsule is intact, no signs of the tumor on the external surface of the body.
  3. No malignant cells in the lavages of the peritoneal cavity.
  4. Poorly differentiated tumor type.

"Disadvantaged groups" is identified as follows:

  1. Cancer affects the outer surface of the ovaries.
  2. Malignant cells are detected in the washings.
  3. Highly differentiated type of tumors.

Studies have shown that patients of "the favorable group" has not helped the appointment of chemotherapy. On the contrary, those who belonged to the "disadvantaged groups" was useful some form of post-operative treatment of ovarian cancer. However, the exact protocol of yet. Thus, systemic chemotherapy can be considered as an option for patients who are at high risk of relapse.

Stage 2 germ cell tumors

If this disgerminoma treatment of ovarian cancer in Israel may begin with the surgery - total hysterectomy and bilateral salpingo-oophorectomy followed by radiation therapy. However, if the cancer is limited to one ovary and fallopian tube and the corresponding woman wants to have children in the future, it may be performed modified operation - unilateral salpingo-oophorectomy followed by chemotherapy.

When tumors negermigennyh recommend surgical treatment of ovarian cancer - total hysterectomy, bilateral salpingo-oophorectomy - surgery or modified cytoreduction surgery - unilateral salpingo-oophorectomy. After that the chemotherapy.

3 stage epithelial cancer

As in step 1 and 2 of the disease requires surgery - total hysterectomy, bilateral salpingo-oophorectomy, and omentektomiya limfadissektsiya - cytoreduction. Postoperative treatment of ovarian cancer include chemotherapy with / without subsequent surgery to remove the remaining cancer cells.

Stage 3 germ cell tumors

When dysgerminoma therapy begins with surgery - total hysterectomy, bilateral salpingo-oophorectomy - reducing the volume of tumor mass (cytoreduction). If the tumor after surgery has a small size, radiation therapy of abdominal area if significant - performed systemic chemotherapy.

Negerminogennye tumor may need the following programs for the treatment of ovarian cancer:

  1. Surgery, including total hysterectomy, bilateral salpingo-oophorectomy - surgery cytoreduction followed by chemotherapy with (without) additional surgery to remove remaining cancer tissue.
  2. Chemotherapy, then surgery - total hysterectomy, bilateral salpingo-oophorectomy - cytoreduction with (without) additional chemotherapy.

If hit by a malignant process only one side and a woman is planning to children, perform a unilateral salpingo-oophorectomy, followed by treatment with cytostatics ovarian cancer. Recommended intraperitoneal chemotherapy.

Step 4 epithelial ovarian cancer

At this stage of the disease recommend surgery - maximum removal of tumor tissue, followed by combination chemotherapy. Advantages postoperative treatment of ovarian cancer are not established at later stages of the disease (3 and 4). However, due to the risk of distant recurrence of some forms of systemic therapy is considered.

Step 4 germ cell tumors

When dysgerminoma carried radical surgery - total hysterectomy, bilateral salpingo-oophorectomy - debulking surgery followed by treatment of ovarian cancer cytostatics. If some types of tumors persist after chemotherapy, are appointed by the additional courses.

With the defeat of only one ovary and women desire to have a child in the future is possible to conduct a unilateral salpingo-oophorectomy followed by chemotherapy.

The following options are considered in negerminogennyh tumors:

  • Operative intervention - total hysterectomy, bilateral salpingo-oophorectomy - cytoreduction with further ovarian cancer treatment with cytostatics (no) followed by chemotherapy or surgery to remove the remaining cancer tissue.
  • Treatment of chemotherapy, then operation - total hysterectomy, bilateral salpingo-oophorectomy - cytoreduction with (without) additional chemotherapy.

Perhaps a unilateral salpingo-oophorectomy followed by treatment with cytostatics ovarian cancer.

Recurrence of epithelial cancers

To date there is no standard treatment, although clinical trials are conducted, to find out the pros and cons of different methods:

  1. Chemotherapy with further surgery.
  2. New chemotherapy drugs and combinations thereof.
  3. Operation, facilitating the disease symptoms.

Palliative care is an important part of the treatment of ovarian cancer. To ensure the best care physician discusses with the patient the options available. The choice depends on the type of tumor.

Relapse dysgerminomas monitored by chemotherapy (no) radiation therapy. When administered negerminogennyh tumors tend to treatment with cytostatics.

Medical service «Tlv.Hospital» will assist in the organization of treatment of ovarian cancer in the best hospitals in Israel - in the selection of experts, appropriate medical center in all matters of domestic support.

A number of treatment strategies are currently under development. It was carried out in the world of hundreds of clinical studies to evaluate the benefits, safety and side effects of new technologies - targeted and hormonal therapy. The results of many of them are not conclusive.

Targeted therapy

This type of treatment of ovarian cancer can eventually provide some control over the predisposition to cancer. Like other types of cancer, malignant ovarian tumors, scientists believe are the result of genetic mutations. They can be inherited or caused by environmental or other harmful environmental factors.

Genetic engineers plan to correct such injury by transplantation of normal copies of genes into cells with mutations. In addition, genetic manipulation may allow researchers to modify tumor cells so that they destroy themselves, becoming a target for the immune system and increasing their sensitivity to chemotherapy. Also, scientists have spent a lot of time trying to strengthen the stability of the bone marrow cells to chemotherapeutic agents, so drug doses can be increased.

Practical application of targeted therapy is still improving. But the more researchers learn about the genetic makeup of ovarian cancer and its biochemical pathways, the closer they come close to the effectiveness of the methods of targeted therapy.

Hormone treatment of ovarian cancer in Israel

Hormone therapy slows the growth and spread of the disease in the body, changing hormone levels.

Female body produces estrogen, needed for the reproduction process. Even after menopause, a certain amount of hormone continues to be synthesized. Certain types of ovarian cancer, such as stromal and borderline tumors may respond to estrogen. Sometimes doctors recommend treatments that block hormone production.

In the course of hormonal treatment of ovarian cancer in Israel is most often used:

  • Antiestrogen drugs which prevent the process of obtaining an estrogen cancer cells by blocking the receptors. The most common drug - tamoxifen (Nolvadex, Tamofen).
  • aromatase inhibitors stop the synthesis or block the action of the aromatase enzyme, which is involved in estrogen production in the body, reducing its content in the final result. These drugs include letrozole (Femara) and anastrozole (Arimidex).

Among the potential adverse effects of the hormonal treatment of ovarian cancer is called the following complications:

  • nausea and vomiting;
  • edema and weight gain;
  • decreased libido;
  • the symptoms of menopause;
  • infertility;
  • diarrhea;
  • fatigue;
  • pain in the muscles and joints;
  • osteoporosis.

Studies of hormone therapy

Over the past few decades, there are many reports of scientists about the potential benefits of hormone replacement therapy in patients whose body does not respond to conventional therapy. For example, people with epithelial cancer resistant to treatment when they were involved:

  • Progesterone - female hormone in the formulations: Provera (medroxyprogesterone), Depo-Provera (medroxyprogesterone acetate suspension), megeys (megestrol acetate).
  • Estrogens, eg, diethylstilbestrol (DES).
  • Combination preparations containing estrogens and progestins.
  • Antiestrogens, such as Nolvadex (tamoxifen).
  • Androgens - male sex hormones, Halotestin (fluoxymesterone).
  • Gonadotropin-releasing hormone (LH).

Unfortunately, responses to this treatment of ovarian cancer were variable, not fixed efficacy of these drugs in controlling the disease. According to the researchers, some results showed antiestrogen therapy for tumors with estrogen receptors. Moreover, the recent results of scientific papers suggest that hormone replacement therapy does not harm the women who were treated for epithelial ovarian cancer. However, according to some physicians, this therapy is controversial, because the use of estrogen may increase the risk of relapse when high-grade endometrioid carcinoma, hormone-sensitive because it is. While there is no conclusive evidence that the use of estrogen in the treatment of such patients is risky or safe.

prices for treatment

With the help of our medical center you will be able to choose the clinic that is more suitable for you, and where you will be treated by specialists especially in the area of ​​oncology reproductive system. In Israel and running the diagnostic program, there are different methods of treatment, with the prices that you find below.

The examination program:

  1. Onkginekolog - $ 590.
  2. Blood tests - $ 550.
  3. Two tests for tumor markers - $ 240.
  4. Revision biopsy - $ 680.
  5. PET-CT - 1670 $.

Total: $ 3,730.

Surgery:

  1. Laparoscopic resection - $ 15,000.
  2. Histology remote biopsy - $ 1170.
  3. Materials for operation - $ 1,500.

Total: 17600

And additional treatment. procedure:

  1. Chemotherapy - $ 1080.
  2. US - $ 320.
  3. Radiotherapy - $ 140.
  4. Immunotherapy - $ 2300.
  5. Biopsy and histology - $ 3300.

Details of the treatment and the exact prices you will find on the phone. Use the form below to submit your application and send documents with the diagnosis.

Consultations with video online a leading Israeli experts: about the benefits of online video Consultation.